Research sharpens our focus on the hidden truths of our world

Research

Dr. RK's research department serves as a cornerstone of innovation and medical advancement. Our team of experienced and dedicated professionals is actively exploring new and better treatments, breakthrough therapies, and improved patient care.

Through rigorous studies and clinical trials, we are pushing the boundaries of medical knowledge to enhance the well-being of our patients and contribute to the ever-evolving field of healthcare.

To be a pioneering centre of research excellence, fostering innovation, and shaping the future of knowledge across diverse domains. We aim to push the boundaries of understanding, improve the human condition, and contribute to global progress through impactful research initiatives.

Our Vision

IEC Approval for Clinical trials and BA/BE Studies
Clinical Trials
Investigator Initiated Trials
Medical Device and Diagnostics Validation
Protocol Development
AI /Wearable devices /Soft wares
Archival Facility
Statistical Analysis

Collaboration with SS Clini Research LLP, a Site Management Organization for clinical trial-related services

Our Comprehensive Services

A Non-Invasive Real-Time Foot Abnormality detection system-Foot Assessment App
Exploring Evolution in Bacterial Spectrum of Diabetic Foot Ulcer Patterns: A Comparative Analysis between Pre-COVID and Post-COVID Eras
The clinical status of the other limb in patients with diabetic foot ulcers
Understanding the causality of foot ulcers in diabetic patients
A Study On The Importance Of Educating Chennai Based Population With Diabetic Mellitus On Diabetic Foot Care: Survey Research In North Chennai
Autologous Platelet-rich fibrin Matrix - an emerging potential therapy for the treatment of Diabetic non healing foot ulcers

What we are currently working on

The Diabetic Foot Assessment App - Patent No. 42479

Our Patent Granted

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To access the Patent

Rastogi, Ashu & Kulkarni, Sudhir & Agarwal, Sanjay & Akhtar, Murtaza & Arsule, Sachin & Bhamre, Sudhir & Bhosle, Deepak & Desai, Sanjay & Deshmukh, Manisha & Giriraja, K & Jagannath, Jagannath & Kashiva, Reema & Rajesh Kesavan, Rajesh & Khandelwal, Deepak & Kolte, Sanjay & Kongara, Srikanth & Darivemula, Anil & Madhusudan, C & Qureshi, Mohammad & Unnikrishnan, Ambika. (2023). Topical Esmolol Hydrochloride as a Novel Treatment Modality for Diabetic Foot Ulcers: A Phase 3 Randomised Clinical Trial. JAMA network open. 6. e2311509. 10.1001/jamanetworkopen.2023.11509.

K, H. & Rajan, Teena & Ravichandran, Jayasuriya & Umapathy, Dhamodharan & Kesavan, Rajesh & Ramkumar, K.M. (2022). IDF21-0264 Profiling of HDACs and its correlation with Nrf2 in patients with diabetic foot ulcer among South Indian population. Diabetes Research and Clinical Practice. 186. 109430. 10.1016/j.diabres.2022.109430.

Kesavan R , Sasikumar CS .Clinical significance of a novel imaging device to evaluate infection on wounds: Performance comparison with culture method and metagenome sequencing. Journal of Wound Management Volume 23, Issue 3: Pages: 182 to 192. DOI: https://doi.org/10.35279/jowm2022.23.03.06

Rajan, Teena & Umapathy, Dhamodharan & Ravichandran, Jayasuriya & Ali, Daoud & Kesavan, Rajesh & Ramkumar, Kunka. (2020). Analysis of the Exonic Single Nucleotide Polymorphism rs182428269 of the NRF2 Gene in Patients with Diabetic Foot Ulcer. Archives of Medical Research. 52. 10.1016/j.arcmed.2020.10.011.

Rajesh Kesavan, Changam Sheela Sasikumar. Efficacy of topical mupirocin versus 2% mupirocin in novel Cogen-S base in chronic skin ulcers: a pilot study.Wounds Asia 2022 | Vol 5 Issue 1 | ©Wounds Asia 2022 www.woundsasia.comhttps://www.woundsasia.com/journals/issue/659

Kesavan R, Sheela Sasikumar C, Narayanamurthy VB, Rajagopalan A, Kim J. Management of Diabetic Foot Ulcer with MA-ECM (Minimally Manipulated Autologous Extracellular Matrix) Using 3D Bioprinting Technology - An Innovative Approach. Int J Low Extrem Wounds. 2021 Oct 12:15347346211045625. doi: 10.1177/15347346211045625

Rajesh Kesavan, Changam Sheela Sasikumar, Yuwanesh Thirunawkkarasu. Efficacy of Oral Protein Supplementation “PRO 360 Diabetic” on Diabetic Foot Ulcer Patients-A Pilot study. Journal of Food Science and Nutrition Research 3 (2020): 195-205.

Kesavan R., Sasikumar, C. S., & Gandeban, A.(2020). Onychocryptosis complicated with osteomyelitis – A case report from tertiary wound care centre in South India. Indian Journal of Case Reports, 6(9), 523–525. https://doi.org/10.32677/IJCR.2020.v06.i09.014

Karan Naresh Amin, Dhamodharan Umapathy, Arunkumar Anandharaj, ,Ravichandran Changam Sheela Sasikumar, Sathish Kumar Rajappan Chandra, Rajesh Kesavan, Ramkumar Kunka Mohanram. miR-23c regulates wound healing by targeting stromal cell-derived factor-1α(SDF-1α/CXCL12) among patients with diabetic foot ulcers. Microvascular Research Volume 127,January 2020, 103924. https://doi.org/10.1016/j.mvr.2019.103924

Umapathy Dhamodharan PhD Rajan Teena MSc Ramachandran Vimal Kumar MSc Sheela Sasikumar Changam PhD Kunka Mohanram Ramkumar PhD Kesavan Rajesh. Circulatory levels of B‐cell activating factor of the TNF family in patients with diabetic foot ulcer: Association with disease progression. Volume27, Issue September/October 2019 Pages 442-449

Rajesh Kesavan, Changam Sheela Sasikumar, Aravind Chandrasekar. Evaluation of amputation risk in diabetic foot ulcer patients infected with Acinetobacter baumannii from a Tertiary Care Centre in South India. International Archives of BioMedical And Clinical Research.2018; 4(4):59-62

Rajesh Kesavan, Changam Sheela Sasikumar and Vimalkumar Ramachandran. A Case Study on Antibiotic Loaded CalciumSulphate Beads in the Management of Diabetic Foot Complications. Int J Foot Ankle 2018,2(1) :1-3

Rajan, Teena & Umapathy, Dhamodharan & Ali, Daoud & Kesavan, Rajesh & Ramkumar, Kunka. (2020). Gene Expression Profiling of Multiple Histone Deacetylases (HDAC) and Its Correlation with NRF2-Mediated Redox Regulation in the Pathogenesis of Diabetic Foot Ulcers. Biomolecules. 10. 10.3390/biom10101466.

Rastogi, Ashu & Goyal, Ghanshyam & Kesavan, Rajesh & Bal, Arun & Bhansali, Anil & Kumar, Harish & Mangalanadanam, & Kamath, Priyatham & Jude, Edward & Armstrong, David. (2020). Long term Outcomes after Incident Diabetic Foot Ulcer: Multicenter Large Cohort Prospective Study (EDI-FOCUS investigators) Epidemiology of Diabetic Foot Complications Study. Diabetes Research and Clinical Practice. 162. 108113. 10.1016/j.diabres.2020.108113.

Rastogi, Ashu & Goyal, Ghanshyam & Kesavan, Rajesh & Bal, Arun & Bhansali, Anil & Kumar, Harish. (2019). Long Term Outcomes Amongst Asian Indians With Diabetic Foot Ulcer: A Large, Multicenter, Nested Cohort Study (EDI-FOCUS investigator

Umapathy, Dhamodharan & Vikraman, Pooja & Alladi, Vaishnavi & Arumugam, Somasundar & Dornadula, Sireesh & Amin, Karan & Kesavan, Rajesh & Mohanran, Ramkumar. (2019). 33-LB: Nuclear Factor Erythroid 2 Related Factor 2 (Nrf2) Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers. Diabetes. 68. 33-LB. 10.2337/db19-33-LB.

Umapathy, Dhamodharan & Rajan, Teena & Kesavan, Rajesh. (2019). Circulatory Levels of B-cell activating factor of the TNF family (BAFF) in Patients with Diabetic Foot Ulcer: Association with Disease Progression. Wound Repair and Regeneration.

Rastogi, Ashu & Bhansali, Anil & Kesavan, Rajesh. (2019). Abstract #338 Mortality Amongst Asian Indians with Diabetic Charcot Neuroarthropathy: A Prospective, Multicenter, Nested Cohort Analysis. Endocrine Practice. 25. 148. 10.1016/S1530-891X(20)46682-0.

Umapathy, Dhamodharan & Dornadula, Sireesh & Rajagopalan, Arvind & Murthy, Narayana & Vairamani, Mariappanadar & Kesavan, Rajesh & Mohanram, Ramkumar. (2017). Potential of circulatory procalcitonin as a biomarker reflecting inflammation among South Indian diabetic foot ulcers. Journal of Vascular Surgery. 67. 10.1016/j.jvs.2017.02.060

Rajan, Teena & Umapathy, Dhamodharan & Ali, Daoud & Kesavan, Rajesh & Ramkumar, Kunka. (2020). Genetic Polymorphism of the Nrf2 Promoter Region (rs35652124) Is Associated with the Risk of Diabetic Foot Ulcers. Oxidative Medicine and Cellular Longevity. 2020. 1-9. 10.1155/2020/9825028.

Rastogi, Ashu & Kesavan, Rajesh & Bal, Arun & Murthy, Narayana. (2020). Guidance for diabetic foot management during COVID-19 pandemic. Journal of Endovascular Surgery. 7. 116-120. 10.4103/ijves.ijves_43_20.

Ravichandran, Jayasuriya & Umapathy, Dhamodharan & Amin, Karan & Anandharaj, Arunkumar & Kesavan, Rajesh & Ramkumar, Kunka. (2020). Role of Nrf2 in MALAT1/ HIF-1α loop on the regulation of angiogenesis in diabetic foot ulcer. Free Radical Biology and Medicine. 156. 10.1016/j.freeradbiomed.2020.05.018.

Viswanathan, Vijay & Kesavan, Rajesh & Vijayan, Kavitha. (2012). Evaluation of Rogers Charcot foot classification system in South Indian diabetic subjects with Charcot foot. JDiabetic Foot Complications. 4. 67-70.

Viswanathan, Vijay & Kesavan, Rajesh & Vijayan, Kavitha & Kumpatla, Satyavani. (2011). A pilot study on the effects of a polyherbal formulation cream on diabetic foot ulcers. The Indian journal of medical research. 134. 168-73.

Kesavan, Rajesh & Viswanathan, Vijay & Ms.Sivagami, & Ms.Kavitha, & Babu, Dr.Mary & Ms.Ramya, & Mohan, Viswanathan. (2007). Efficacy of Recombinant Human Epidermal Growth Factor (Regen D 150) in Healing Diabetic Foot Ulcers. Diabetes Res ClinPract

Vijayan, Kavitha & Kesavan, Rajesh & Viswanathan, Vijay. (2007). Vacuum Assisted Closure- Advanced Therapy System in healing Diabetic foot ulcers.

Our Publications

Name and Designation of the Members

Mr. M. Jeeva

Chairman

Dr Rajesh Kesavan

Member Secretary

Dr S Ramya

Medical Scientist

Dr D Darwin Britto

Clinician

Dr Deepa. B

Legal Expert

Mr. Ganesan R

Lay Person

Ms. Savitha R

Social Scientist

Dr C Sheela Sasikumar

Scientific Member

Dr. Socakalingam M

Member

The IEC Composition

The primary responsibility of Dr. RK Diabetic Foot – Institutional Ethics Committee (RKDF -IEC) is to safeguard the rights, safety, and welfare of research participants. The IEC holds regular meetings to review research proposals and provide suggestions to investigators to ensure their research meets ethical standards before approval.